To cancel the fraction, we need to find the greatest common divisor (GCD) of the numerator and denominator and divide both by it.

The GCD of 125 and 64 is 1. The GCD of 48 and 45 is 3.

Dividing both the numerator and denominator by their respective GCDs, we get:

125/64 × 48/-45 = (125 ÷ 1) / (64 ÷ 1) × (48 ÷ 3) / (-45 ÷ 3) = 125/64 × 16/-15 = (125 × 16) / (64 × -15) = 2000 / -960 = -125/64