To subtract these fractions, we need to find a common denominator. The least common denominator (LCD) for 2 and 42 is 42.

Converting the fractions to have a denominator of 42:

5/2 = (5/2) * (21/21) = 105/42 22/42 = 22/42

Now we can subtract the fractions:

105/42 - 22/42 = (105 - 22)/42 = 83/42

Therefore, the result of subtracting 5/2 - 22/42 is 83/42.