Sure! Here’s a math worksheet with multiplication problems involving 4-digit by 2-digit numbers:

1. 3,245 x 56 =
2. 4,789 x 32 =
3. 2,156 x 78 =
4. 6,432 x 45 =
5. 8,765 x 21 =
6. 9,876 x 67 =
7. 5,432 x 89 =
8. 7,654 x 43 =
9. 1,234 x 76 =
10. 3,210 x 98 =

Remember to show your work and write the answers in the space provided. Good luck!