Simoun - The main character of the novel, who is also known as Crisostomo Ibarra. He is a wealthy and influential man who seeks revenge against the Spanish government for the injustices he has suffered.

Basilio - A young man who is the son of Sisa, a character from the previous novel, Noli Me Tangere. He is a medical student who becomes involved in Simoun’s plans for revolution.

Isagani - A young man who is a student at the Ateneo de Manila. He is in love with Paulita Gomez, but their relationship is complicated by their differing political views.

Paulita Gomez - A beautiful young woman who is the object of Isagani’s affections. She is the daughter of a wealthy businessman who is involved in corrupt practices.

Padre Florentino - A wise and compassionate priest who serves as a mentor to Simoun and other characters in the novel. He is a symbol of hope and redemption.

Don Custodio - A corrupt government official who is obsessed with his own power and wealth. He is a symbol of the greed and corruption that pervades the Spanish colonial system.

Ben Zayb - A journalist who is known for his sensationalist reporting. He is a symbol of the media’s role in shaping public opinion and perpetuating stereotypes.

Elías - A revolutionary who is seeking to overthrow the Spanish government. He is a symbol of the struggle for freedom and independence.

Maria Clara - The love interest of Crisostomo Ibarra in the previous novel, Noli Me Tangere. She is now a nun who has renounced the world and its injustices.

Tarsilo and Bruno - Two young men who are involved in the revolution. They are symbols of the sacrifices that ordinary people make in the struggle for freedom.