To calculate the drop rate, we need to determine the number of drops per minute.

First, we need to convert the volume of platelets from milliliters to drops. Since the drop factor is 15, we can multiply the volume in milliliters by 15 to get the volume in drops.

375 mL * 15 drops/mL = 5625 drops

Next, we need to determine the duration of the transfusion in minutes. Since the transfusion is to be administered over 2 hours, we can multiply 2 hours by 60 minutes per hour to get the duration in minutes.

2 hours * 60 minutes/hour = 120 minutes

Finally, we can divide the total number of drops by the duration in minutes to calculate the drop rate.

5625 drops / 120 minutes = 46.875 drops per minute

Therefore, the drop rate for the transfusion is approximately 46.875 drops per minute.