Let’s assume that Ram originally had x amount of money. After losing 20% of his money, he has (100% - 20%) = 80% of his money left. So, he has (80/100) * x = 0.8x amount of money left. After spending 25% of the remainder, he has (100% - 25%) = 75% of the remainder left. So, he has (75/100) * 0.8x = 0.6x amount of money left. According to the given information, 0.6x = 480. Therefore, x = 480 / 0.6 = 800. Hence, Ram originally had Rs. 800. Answer: \boxed{800}.